🧪 Supplement
resveratrol
A red-wine polyphenol marketed for longevity. It does NOT directly activate SIRT1 as originally claimed, and lifespan extension is contested — the foundational mechanism behind the hype did not hold up.
0 well-supported · 1 disputed. This shows how settled each sub-question is, not whether resveratrol is "good." Direction lives in each claim below.
The 2 claims about resveratrol
Each keeps its own verdict — we never average them away.
Does resveratrol have real evidence it extends human lifespan or healthspan?
Contested Correct — no human longevity outcome exists and human metabolic RCTs are inconsistent/mostly null, so his dismissal of a longevity benefit holds (though "no effect whatsoever" would overreach).
Does resveratrol switch on the longevity gene SIRT1?
Leans against Probably not — four independent labs showed the original finding was a lab-test quirk, only ever seen in the lab.
Educational only, not medical advice. Hub descriptions are curated for honesty; see the methodology.